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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
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Phase-engineered MoS2 nanosheets/probiotic vesicles hydrogel for diabetic wound healing via dynamic ROS modulation
Yu-Sen Zhang1,2, Shuai Ke1,2, Jia Zhang1,2
1Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Journal of Nanobiotechnology
|April 29, 2026
Summary
This study presents a smart hydrogel that uses engineered nanosheets and vesicles to control reactive oxygen species (ROS) for improved diabetic wound healing. The system effectively combats infection and inflammation by dynamically modulating the wound environment.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Diabetic wound repair is a significant clinical problem, often complicated by infection and immune dysregulation.
- Current nanomaterial dressings lack intelligent modulation of reactive oxygen species (ROS) for optimal immune microenvironment control.
- Developing advanced therapies that address both infection and inflammation is crucial for effective diabetic wound management.
Purpose of the Study:
- To develop a glucose-responsive hydrogel system integrating 1T-MoS2 nanosheets and L. reuteri-derived extracellular vesicles (LEVs) for dynamic ROS modulation in diabetic wounds.
- To investigate the synergistic effects of the nanozyme-LEVs system in combating pathogens and regulating the immune microenvironment for enhanced diabetic wound healing.
- To provide an intelligent and precise therapeutic strategy for managing complex diabetic wound conditions.
Main Methods:
- Fabrication of a glucose-responsive hydrogel using dynamic borate ester crosslinks.
- Integration of phase-engineered 1T-MoS2 nanosheets and L. reuteri-derived extracellular vesicles (LEVs) into the hydrogel matrix.
- Evaluation of the hydrogel's degradation, ROS generation via 1T-MoS2 peroxidase-like activity under NIR irradiation, and LEV-mediated macrophage polarization.
Main Results:
- The hydrogel demonstrated glucose-responsive degradation, releasing 1T-MoS2 nanosheets and LEVs in diabetic wound environments.
- Released 1T-MoS2 nanosheets effectively generated ROS under NIR irradiation, enhancing pathogen and biofilm elimination by catalyzing H2O2 and depleting GSH.
- LEVs promoted M2 macrophage polarization by restoring mitochondrial function, reducing ROS, and suppressing NF-κB activation, thereby alleviating inflammation.
Conclusions:
- The integrated nanozyme-LEVs hydrogel system offers a synergistic approach to diabetic wound healing by adaptively modulating ROS.
- This intelligent system effectively addresses both infection and immune dysregulation, crucial challenges in diabetic wound management.
- The developed therapeutic strategy shows promise for precise and advanced diabetic wound care.
