Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

1.0K
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
1.0K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

1.7K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.7K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

1.2K
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.2K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

981
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
981
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.3K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.3K
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

1.1K
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive analysis of spatial heterogeneity reveals the important role of the upper-layer fermented grains in the fermentation and flavor formation of <i>Qingxiangxing baijiu</i>.

Food chemistry: X·2024
Same author

Equalization of RGB coupling efficiencies of metasurface waveguide coupler by adjusting imaginary part of refractive index.

Optics express·2024
Same author

Performance evaluation and comparative research of underwater wireless optical communication system by using different structured beams.

Journal of the Optical Society of America. A, Optics, image science, and vision·2024
Same author

Generation of multi-focus shaping with high uniformity based on an improved Gerchberg-Saxton algorithm.

Applied optics·2024
Same author

Efficacy of tacrolimus monotherapy in primary membranous nephropathy.

Open medicine (Warsaw, Poland)·2024
Same author

Investigating retinal explant models cultured in static and perfused systems to test the performance of exosomes secreted from retinal organoids.

Journal of neuroscience methods·2024
Same journal

[Medical Damage Identification of CT Guided Pulmonary Nodule Localization Needle Escapes to the Left Ventricle： A Case Report].

Fa yi xue za zhi·2026
Same journal

[Forensic Identification of a Fatality from Confined Container Deflagration Complicated by Tertiary Blast Injury： A Case Report].

Fa yi xue za zhi·2026
Same journal

[Fatal Rupture of the Abdominal Aorta Caused by Trampling： A Case Report].

Fa yi xue za zhi·2026
Same journal

[Multidisciplinary Identification in a Hit-and-Run Traffic Accident： A Case Report].

Fa yi xue za zhi·2026
Same journal

[Comprehensive Identification of the Vulnerant by Examining Marks on Clothing and Bodies Combining with Trace Comparison： A Case Report].

Fa yi xue za zhi·2026
Same journal

[Letter to the Editor： On Critical Toxicological Information of Newly Discovered Toxic Substances and Illegal Drugs].

Fa yi xue za zhi·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

14.1K

[Synthetic Drug： Pregabalin].

Hang Chen1, Xin Wang1, Hui Yan1

  • 1Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.

Fa Yi Xue Za Zhi
|April 29, 2026
PubMed
Summary
This summary is machine-generated.

Deaths from pregabalin misuse are rising, necessitating forensic toxicology data. This review covers pregabalin

Keywords:
forensic medicinein vivo processpharmacological effectspregabalinsymptoms of poisoningtoxicological analysis

More Related Videos

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

26.5K
Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
18:01

Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants

Published on: August 18, 2008

13.8K

Related Experiment Videos

Last Updated: Apr 30, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

14.1K
Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

26.5K
Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
18:01

Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants

Published on: August 18, 2008

13.8K

Area of Science:

  • Forensic Toxicology
  • Pharmacology

Background:

  • Pregabalin, a gamma-aminobutyric acid derivative, is increasingly associated with drug abuse and fatalities.
  • A growing number of deaths linked to pregabalin misuse highlight an urgent need for forensic toxicological data.

Purpose of the Study:

  • To systematically review the pharmacology, toxicity, and poisoning symptoms of pregabalin.
  • To consolidate toxicological data from reported cases for forensic identification reference.

Main Methods:

  • Systematic review of domestic and international research.
  • Analysis of pharmacological effects, toxicity data, and poisoning symptoms.
  • Compilation of toxicological data from typical poisoning cases.

Main Results:

  • The review synthesizes comprehensive information on pregabalin's effects and toxicity.
  • It includes data on in vivo processes and case studies relevant to forensic analysis.

Conclusions:

  • This review provides essential forensic toxicological information on pregabalin.
  • It serves as a valuable reference for identifying pregabalin-related poisoning and fatalities.