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Updated: Apr 30, 2026
07:16
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
14.1K
[Synthetic Drug： Pregabalin].
Hang Chen1, Xin Wang1, Hui Yan1
1Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
Fa Yi Xue Za Zhi
|April 29, 2026
Summary
Deaths from pregabalin misuse are rising, necessitating forensic toxicology data. This review covers pregabalin
Area of Science:
- Forensic Toxicology
- Pharmacology
Background:
- Pregabalin, a gamma-aminobutyric acid derivative, is increasingly associated with drug abuse and fatalities.
- A growing number of deaths linked to pregabalin misuse highlight an urgent need for forensic toxicological data.
Purpose of the Study:
- To systematically review the pharmacology, toxicity, and poisoning symptoms of pregabalin.
- To consolidate toxicological data from reported cases for forensic identification reference.
Main Methods:
- Systematic review of domestic and international research.
- Analysis of pharmacological effects, toxicity data, and poisoning symptoms.
- Compilation of toxicological data from typical poisoning cases.
Main Results:
- The review synthesizes comprehensive information on pregabalin's effects and toxicity.
- It includes data on in vivo processes and case studies relevant to forensic analysis.
Conclusions:
- This review provides essential forensic toxicological information on pregabalin.
- It serves as a valuable reference for identifying pregabalin-related poisoning and fatalities.
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