Modern Mining: The Role of Single-cell RNA Sequencing in Advancing Neuroscience Research

The brain's vast cellular diversity and complex developmental programs have long inspired neuroscientists' efforts to understand its organization and function. Recent advances in single-cell RNA sequencing (scRNA-seq) have transformed this field, enabling the characterization of neural and glial cell types with unprecedented resolution. This had allowed us to better understand the developmental trajectories and functional specialization of cell types across multiple model organisms, from zebrafish and fruit flies, to mice and humans, but also to address the mechanisms underlying neural disease progression.