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Comprehensive mapping of Neurofibromin (NF1) expression in developing mouse brain.

Vishal Lolam1, Achira Roy1

  • 1Neurodevelopment Laboratory, Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), India.

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|April 29, 2026
PubMed
Summary
This summary is machine-generated.

Neurofibromin (NF1) expression in the developing mouse brain was mapped, revealing graded patterns across regions and cell types. This atlas aids understanding of NF1

Keywords:
NF1brain expressioncerebellumneurodevelopmentsingle-cell reanalysis

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Neurofibromin (NF1) regulates the RAS-RAF-ERK pathway, crucial for neurodevelopment.
  • Mutations in NF1 are linked to neurodevelopmental disorders.
  • A detailed map of NF1 expression in the developing brain is lacking.

Purpose of the Study:

  • To create a comprehensive spatiotemporal atlas of NF1 expression in the developing mouse brain.
  • To elucidate why specific cell populations are vulnerable to NF1 loss.
  • To provide a framework for studying NF1-associated brain disorders.

Main Methods:

  • Utilized in situ hybridization and immunohistochemistry to characterize NF1 distribution.
  • Integrated findings with single-nuclei RNA-sequencing (snRNA-seq) data from adult mouse brains.
  • Analyzed NF1 expression from embryonic to postnatal developmental stages.

Main Results:

  • Revealed a previously undocumented graded expression pattern of NF1.
  • Demonstrated distinct NF1 distribution across various brain regions and cell lineages.
  • Identified unique sub-lineages of neural cells with specific NF1 expression profiles.

Conclusions:

  • The study provides a high-resolution map of NF1 expression in the developing brain.
  • Findings enhance understanding of NF1's fundamental role in brain development.
  • The atlas serves as a crucial resource for investigating NF1-related neurodevelopmental disorders.