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Towards a framework for prioritizing diagnostics in the global AMR response.

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Prioritizing antimicrobial resistance (AMR) diagnostics is crucial. A new framework integrates problem scale, implementability, impact, and need to guide resource allocation for better patient outcomes and antimicrobial stewardship.

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Area of Science:

  • Medical diagnostics
  • Infectious disease epidemiology
  • Public health policy

Background:

  • Antimicrobial resistance (AMR) diagnostics are vital for patient care and antimicrobial stewardship.
  • Current prioritization methods for AMR diagnostics are fragmented and lack real-world impact linkage.
  • Existing frameworks often assess diagnostic aspects in isolation, limiting guidance for resource-constrained settings.

Purpose of the Study:

  • To propose a pragmatic framework for prioritizing antimicrobial resistance diagnostics.
  • To integrate key domains for decision-oriented prioritization.
  • To guide global and national agendas for AMR diagnostic development and implementation.

Main Methods:

  • Development of a novel prioritization framework for AMR diagnostics.
  • Integration of four key domains: scale of the problem, implementability, diagnostic impact, and unmet need.
  • Emphasis on surfacing trade-offs for structured decision-making.

Main Results:

  • The proposed framework facilitates weighted, decision-oriented prioritization over ad hoc or market-driven selection.
  • It provides a structured mechanism for global AMR agenda setting and national/local priority translation.
  • The framework helps identify high-priority use cases, such as rapid diagnostics for neonatal sepsis.

Conclusions:

  • A structured, multi-domain framework is essential for effective AMR diagnostic prioritization.
  • This approach supports informed policy, investment, and innovation for critical AMR diagnostic needs.
  • Prioritizing diagnostics like those for neonatal sepsis can drive coordinated global and local action.