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Related Experiment Video

Updated: Apr 30, 2026

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
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Transrectal Ultrasound-Guided Prostate Biopsy: Sextant versus 12-Core Protocol.

Adedeji Lukman Fatuga1, Kehinde H Tijani1, Rufus W Ojewola1

  • 1Department of Surgery, Lagos University Teaching Hospital, Lagos, Nigeria.

Journal of the West African College of Surgeons
|April 29, 2026
PubMed
Summary
This summary is machine-generated.

An extended 12-core prostate biopsy protocol significantly improves prostate cancer detection rates compared to the standard sextant protocol. This enhanced method is crucial for accurate diagnosis in suspected cases.

Keywords:
Prostate cancerprostate core biopsy protocolprostate needle biopsytransrectal ultrasound (TRUS)

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Prostate cancer is the most common cancer in Nigerian men.
  • Prostate biopsy is essential for diagnosis.
  • Transrectal ultrasound (TRUS)-guided needle biopsy is the standard procedure.

Purpose of the Study:

  • To compare cancer detection rates between sextant and extended 12-core biopsy protocols.
  • To evaluate TRUS-guided needle biopsy efficacy in suspected prostate cancer.

Main Methods:

  • Prospective comparative study at Lagos University Teaching Hospital.
  • 138 men underwent TRUS-guided extended 12-core prostate needle biopsy.
  • Compared sextant and extended 12-core protocols using statistical analysis.

Main Results:

  • Extended 12-core biopsy detected 98.7% of cancers versus 78.2% for sextant protocol.
  • Overall cancer detection improved by 21.8% with the extended protocol (P < 0.001).
  • Improvement was significant, especially in lower PSA ranges (≤20 ng/mL).

Conclusions:

  • Extended 12-core biopsy protocol is significantly superior to the sextant protocol.
  • Increasing biopsy cores enhances prostate cancer detection rates.
  • Combined screening modalities improve predictive value for cancer detection.