Microbial control and a simple regenerative endodontic protocol achieve durable apical healing and long-term root...

Area of Science:

• Endodontics
• Regenerative Medicine
• Dental Traumatology

Background:

• Immature teeth with necrotic pulps and apical periodontitis require advanced treatment.
• Apexification is a traditional approach, but regenerative endodontics offers a biologically driven alternative.

Purpose of the Study:

• To report the long-term management and outcomes of regenerative endodontics in an immature traumatized incisor.

Main Methods:

• A conservative protocol involving disinfection with sodium hypochlorite, triple-antibiotic paste, EDTA irrigation, and collagen matrix placement.
• Apical bleeding induction followed by sealing with white mineral trioxide aggregate.
• Long-term radiographic (periapical, CBCT) and clinical follow-up over 10 years.

Main Results:

• Progressive and stable tissue regeneration observed over a decade.
• Radiographic evidence of hard-tissue deposition, root elongation, and canal wall thickening.
• Clinical confirmation of apical closure, absence of pathology, and pulpal vitality.

Conclusions:

• Meticulous microbial control and a cost-conscious regenerative protocol can achieve durable apical healing and root development.
• Regenerative endodontics is a feasible option for selected immature traumatized incisors with sustained functional recovery.