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The selfish ribosome.

Mart Krupovic1, Eugene V Koonin2

  • 1Institut Pasteur, Université Paris Cité, Cell Biology and Virology of Archaea Unit, Paris, France.

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Summary
This summary is machine-generated.

The ribosome, crucial for protein synthesis, may have originated as a symbiotic partner. It evolved into a dominant cellular component, consuming resources to ensure its own propagation.

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Area of Science:

  • Molecular Biology
  • Origin of Life Studies
  • Evolutionary Biochemistry

Background:

  • The ribosome is central to cellular life, synthesizing proteins and consuming significant cellular energy.
  • Understanding the ribosome's evolutionary origins is key to deciphering early life.

Purpose of the Study:

  • To propose a novel hypothesis for the evolutionary origin of the ribosome.
  • To reframe the ribosome's role in cellular evolution as a 'selfish element'.

Main Methods:

  • This study is primarily theoretical, drawing on existing knowledge of molecular biology and evolutionary theory.
  • It involves constructing a narrative based on the proposed stages of early life evolution.

Main Results:

  • The ribosome likely originated as a mutualistic symbiont with an RNA polymerase ribozyme, providing peptides to enhance RNA replication.
  • The transition to the RNA-protein world led to cellular dependence on the ribosome for essential replication proteins.
  • The ribosome's evolution is characterized as a 'takeover,' optimizing resource consumption for its own propagation.

Conclusions:

  • The ribosome's emergence was a pivotal event, driving the transition from an RNA-based to an RNA-protein-based world.
  • The ribosome can be viewed as the ultimate 'selfish genetic element,' manipulating cellular resources for its perpetuation.
  • This perspective offers new insights into cellular evolution and the fundamental nature of biological organization.