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Updated: Apr 30, 2026
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Published on: November 4, 2022
Insights into the daily functions of radix Panax notoginseng
Lei Xiao1, Zi-Jian Qiu2, Jing Wu2
1School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology Guangzhou 510641 People's Republic of China.
Abstract:
A total of 48 compounds, including 6 undescribed triterpenoid saponins, notoginsenosides V1-V6 (1-6), were isolated and identified from the radix of Panax notoginseng. Their structures were elucidated by combining various spectroscopic techniques, such as NMR and MS analyses. Among them, (2S)-1-O-(9Z,12Z-octadecadienoyl)-3-O-β-galactopyranosylglycerol (43) exhibited the strongest anti-inflammatory activity against cyclooxygenase-2. The compounds 7, 14, 15, 16, 28, 29, 30, 39, 43, and 45 promoted the proliferation of human oral mucosa fibroblasts (hOMFs). Additionally, the compounds 1, 8, 9, 14, 35, 43, and 45 promoted the proliferation of human dermal papilla cells (hDPCs). These results revealed the potential daily functional benefits of P. notoginseng, including ameliorating oral ulcer conditions and preventing hair loss.
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