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Deriving Health Utilities from the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF) Using Mapping
Adam B Smith1, Tom Bromilow1, Stuart Mealing1
1York Health Economics Consortium, York, UK.
Patient Related Outcome Measures
|April 29, 2026
Summary
Discrete choice experiment (DCE) utilities better capture health-related quality of life (HRQoL) impacts in children with peanut allergies than traditional mapping methods. These DCE utilities are more responsive for economic evaluations of food allergy interventions.
Area of Science:
- Health Economics
- Patient-Reported Outcomes
- Allergy Research
Background:
- Health utilities are crucial for economic evaluations of food allergy interventions.
- Traditional HRQoL instruments may not adequately capture the mental health and daily activity impacts of food allergies in children.
- Developing sensitive health utilities is essential for accurate assessment of interventions.
Purpose of the Study:
- To generate health utilities from the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) using mapping and discrete choice experiment (DCE) methods.
- To compare the responsiveness of mapping-derived versus DCE-derived health utilities.
- To apply these utilities to clinical trial data for evaluating a peanut allergy intervention.
Main Methods:
- Health utilities (HU) were generated using mapping algorithms (FAQLQ-PF to EQ-5D-3L) and a composite DCE.
- Parents of children with peanut allergies (N=159) completed FAQLQ-PF and EQ-5D-Y-Proxy-1.
- A DCE was conducted with parents without peanut-allergic children (N=767).
Main Results:
- The mapping algorithm showed an association of 0.199 between FAQLQ-PF and EQ-5D-3L utilities.
- DCE identified severe food-related anxiety, emotional distress, and social limitations as key disutilities.
- Both methods showed statistically significant HRQoL improvements in clinical trials, but DCE utilities were more responsive.
Conclusions:
- DCE-derived health utilities demonstrate greater responsiveness to HRQoL changes compared to mapped utilities.
- DCE utilities offer improved sensitivity for capturing the impact of peanut allergy interventions on children's quality of life.
- DCE-derived utilities are recommended for economic evaluations and health technology assessments in food allergy.
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