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Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
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Related Experiment Video

Updated: Apr 30, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

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Exploring the Protective Mechanism of Xuebijing Injection Against Sepsis.

Zhouguang Jiao1, Haikuan Yu2, Xuekong Li3

  • 1College of Basic Medical Science, Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Disease of Hebei Province, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei University, Baoding, 071002, People's Republic of China.

Journal of Inflammation Research
|April 29, 2026
PubMed
Summary
This summary is machine-generated.

Xuebijing injection effectively treats sepsis by modulating inflammatory and antioxidant pathways through its bioactive compounds. This study elucidates its herb-compound-gene-pathway network, improving sepsis treatment strategies.

Keywords:
Xuebijing injectionanti-inflammatorynetwork pharmacologysepsistarget gene

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
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Area of Science:

  • Pharmacology
  • Network pharmacology
  • Traditional Chinese Medicine (TCM)

Background:

  • Xuebijing (XBJ) injection, a TCM, is approved for sepsis treatment in China.
  • Its bioactive components and anti-sepsis mechanisms require further elucidation.

Purpose of the Study:

  • To elucidate the regulatory network of herbs, compounds, genes, and signaling pathways involved in XBJ's anti-sepsis effects.
  • To validate the anti-sepsis efficacy of XBJ and its main component, Hydroxysafflor Yellow A.

Main Methods:

  • Network pharmacology analysis integrating RNA-sequencing data and literature review.
  • Validation using a cecal ligation and puncture (CLP)-induced murine sepsis model.

Main Results:

  • XBJ modulates 21 target genes (e.g., IL6, TNF, HMGB1) via at least 18 bioactive compounds.
  • XBJ treatment doubled the survival rate in a murine sepsis model compared to placebo.
  • A comprehensive herb-compound-gene-pathway regulatory network was established.

Conclusions:

  • XBJ alleviates sepsis by modulating target genes through anti-inflammatory and antioxidant pathways.
  • This study provides a systematic elucidation of XBJ's anti-sepsis mechanism.
  • The research strategy offers a framework for studying other TCM formulae.