Emerging Microbiome-Based Therapies for Skin Infections: From Probiotics and Prebiotics to Synthetic Microbiome...

Area of Science:

• Dermatology
• Microbiology
• Biotechnology

Background:

• Skin infections pose a significant global health challenge, exacerbated by rising antimicrobial resistance (AMR) and the limitations of conventional antibiotics.
• The skin microbiome's role in maintaining skin health, preventing pathogen invasion, and modulating immune responses is increasingly recognized.
• Dysbiosis of the skin microbiota is linked to various skin conditions, shifting therapeutic focus from pathogen eradication to microbiome regulation.

Purpose of the Study:

• To review recent advancements in microbiome-based therapies for skin diseases.
• To evaluate the clinical efficacy, safety, and regulatory aspects of these novel treatments.
• To explore the molecular mechanisms and future potential of microbiome-centered approaches in dermatology.

Main Methods:

• Comprehensive literature review of microbiome-based therapies including probiotics, prebiotics, postbiotics, bacteriophages, and microbiome transplants.
• Analysis of synthetic microbiome engineering techniques.
• Examination of clinical trial data, safety profiles, and regulatory hurdles.
• Exploration of molecular underpinnings and multi-omics integration.

Main Results:

• Microbiome-based therapies demonstrate potential in addressing AMR and improving long-term treatment outcomes compared to traditional antibiotics.
• Various approaches like probiotics, bacteriophages, and synthetic consortia show promise in restoring microbial balance.
• Challenges remain regarding clinical effectiveness, safety, and regulatory approval for widespread adoption.

Conclusions:

• Microbiome-based therapies represent a paradigm shift in treating skin diseases, moving towards restoring ecological balance.
• These novel treatments hold significant promise for managing chronic skin conditions and combating AMR.
• Future directions include integrating multi-omics data and AI for personalized microbiome interventions.