Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

2.6K
2.6K
Improving Translational Accuracy02:07

Improving Translational Accuracy

11.5K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.5K
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

6.4K
Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
6.4K
Language and Cognition01:27

Language and Cognition

878
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
878

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of Outcomes Between Two-Screw Proximal Femoral Nail and Halifax Femoral Nail in Elderly Patients With Intertrochanteric Fractures.

Cureus·2026
Same author

Transformative Potentials of Magnetic Micro- and Nanobots Using Programmable Electromagnetic Platforms for Next-Generation Therapeutics and Sensing.

ACS applied bio materials·2026
Same author

Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics.

Journal of molecular biology·2025
Same author

Vanillin restrains proliferation of triple negative breast cancer cells by inducing ferroptosis via mediating the KLF2/GPX4 axis.

Cytotechnology·2025
Same author

Microstructural injury to the optic nerve with vigabatrin treatment in West syndrome: A DTI study.

Scientific reports·2025
Same author

SERUM LncRNA SNHG16: A Biomarker for Diagnosing Childhood Obesity and Predicting Its Progression to Metabolic Syndrome.

Diabetes, metabolic syndrome and obesity : targets and therapy·2025
Same journal

MedQA-CS: Objective Structured Clinical Examination (OSCE)-Style Benchmark for Evaluating LLM Clinical Skills.

Proceedings of the conference. Association for Computational Linguistics. European Chapter. Conference·2026
Same journal

Dialogue is Better Than Monologue: Instructing Medical LLMs via Strategical Conversation.

Proceedings of the conference. Association for Computational Linguistics. European Chapter. Conference·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
03:14

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

1.3K

GRAFF: GRaph-Augmented Fine-grained Fusion for Large Language Models.

Himanshu Chaudhary1, Ruida Wang2, Gowtham Ramesh3

  • 1Department of Computer Sciences, University of Wisconsin-Madison.

Proceedings of the Conference. Association for Computational Linguistics. European Chapter. Conference
|April 29, 2026
PubMed
Summary
This summary is machine-generated.

Large language models (LLMs) struggle with structured data like graphs. Our GRAFF method enhances LLMs by integrating fine-grained graph information, significantly improving graph-based question answering performance.

Related Experiment Videos

Last Updated: Apr 30, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
03:14

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

1.3K

Area of Science:

  • Artificial Intelligence
  • Natural Language Processing
  • Graph Neural Networks

Background:

  • Large language models (LLMs) excel at text generation but face challenges integrating structured data, such as graphs, due to natural language ambiguity and unstructured text.
  • Existing methods for graph integration into LLMs often compress complex graph structures into single tokens, limiting the capture of deep semantic and structural information.
  • This limitation hinders the effective utilization of high-quality structured data in specialized domains by LLMs.

Purpose of the Study:

  • To propose a novel method, GRAFF (Graph-Augmented Fine-grained Fusion), for effectively integrating fine-grained graph structural information into LLMs.
  • To enhance the ability of LLMs to understand and leverage structured data for improved performance in graph-based question answering tasks.
  • To overcome the limitations of existing methods that compress graph information into single tokens.

Main Methods:

  • GRAFF integrates node-level structural information with corresponding text entities using a lightweight structure adapter module.
  • A dual-channel graph input mechanism is introduced to separately encode structural and semantic components, yielding more expressive graph representations.
  • A graph attention (GAT) module is incorporated into the intermediate decoder layers of LLMs to process structural information.

Main Results:

  • GRAFF significantly enhances LLMs' graph-understanding capabilities, particularly in question answering.
  • The proposed method demonstrates superior performance compared to existing baselines across four diverse datasets.
  • GRAFF achieved an average improvement of 10.14% over baseline methods in graph-based question answering tasks.

Conclusions:

  • GRAFF offers an effective approach for integrating fine-grained graph structures into LLMs, addressing limitations of previous methods.
  • The method substantially improves LLMs' performance on graph-based question answering, showcasing its potential for specialized domains.
  • The research provides a valuable contribution to advancing LLM capabilities in handling complex, structured data.