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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Related Experiment Video

Updated: Apr 30, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Cyclodextrin-Based Nanogels with Chemistry-Tunable Intracellular Stability and Distribution.

Ruichen Zhang1, Yanjing Ji1, Patrick van Rijn1

  • 1Department of Biomaterials and Biomedical Technology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

International Journal of Nanomedicine
|April 29, 2026
PubMed
Summary
This summary is machine-generated.

We developed tunable cyclodextrin nanogels (CD-nGels) for drug delivery. By adjusting linkages, we controlled their breakdown inside cells, impacting drug distribution for better therapeutic outcomes.

Keywords:
cyclodextrin-based nanogelshost–guest interactionshydrolytic stabilityintracellular distribution

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Cyclodextrin-based nanogels (CD-nGels) are effective for encapsulating hydrophobic drugs in hydrophilic networks.
  • Host-guest interactions improve drug solubility, stability, and therapeutic efficacy.

Purpose of the Study:

  • To synthesize fluorescent CD-nGels with tunable hydrolytic properties.
  • To investigate the impact of chemical composition on intracellular stability and drug distribution.

Main Methods:

  • Surfactant-free synthesis of Nile Blue-labeled CD-nGels with varying amide and ester linkages.
  • Characterization of nanogel size (247-431 nm) and hydrolytic sensitivity at pH 5.1 and in cell lysate.
  • Encapsulation of Coumarin-6 (C6) and visualization of intracellular distribution via confocal microscopy.

Main Results:

  • Three CD-nGel formulations (NG1, NG2, NG3) showed tunable hydrolytic sensitivity.
  • Intracellular stability was dictated by chemical composition, with ester linkages increasing degradability.
  • CD-nGels demonstrated distinct intracellular fluorescence patterns correlating with degradability, from compact to diffuse.

Conclusions:

  • A modular platform for chemically tuning CD-nGel intracellular stability and distribution was established.
  • This provides a design basis for developing CD-based nanogels for controlled intracellular drug delivery.