Nanotherapy for Pancreatitis: From Single-Cell Targeting Toward Multicellular-Coordinated Regulation

Pancreatitis constitutes a serious global health challenge characterized by a multicellular pathogenesis and limited therapeutic options. The recent discovery of different cellular pathogenic mechanisms and the emerging effectiveness of nanotechnology-based, cell-targeted therapies have provided promising therapeutic avenues for pancreatitis. However, the identification of effective cellular targets, the elucidation of nanotherapeutic mechanisms, and the multicellular-coordinated modulation remain fragmented and insufficiently defined. Here, we summarize recent progress in understanding pathogenic mechanisms from the perspective of different cell populations and analyze relevant nanotechnology-based approaches designed to target these cells in detail. By bridging different cellular pathogenesis with advances in nanotherapeutic design, this review offers a clear framework for cell-targeted nanotherapeutics across the disease progression, proposing pathological and methodological insights to guide the future development of multicellular-coordinated nanomedicines for pancreatitis.