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Related Experiment Video

Updated: Apr 30, 2026

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
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Consensus Review: Predicting Recurrence in Chronic Rhinosinusitis With Nasal Polyps: Multidisciplinary Insights From

Isam Alobid1, Sandra Domínguez2, Christian Calvo-Henriquez3

  • 1Rhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clínic, IDIBAPS, CIBERES, Universitat de Barcelona, Spain.

Journal of Investigational Allergology & Clinical Immunology
|April 29, 2026
PubMed
Summary

Defining recurrence in chronic rhinosinusitis with nasal polyps (CRSwNP) is crucial for effective treatment. This study established a clear definition and identified key prognostic factors like eosinophilic CRSwNP and asthma to predict recurrence.

Keywords:
Chronic rhinosinusitis with nasal polyps (CRSwNP)Delphi studyMultidisciplinaryPostsurgical recurrencePrognostic factorsRELAPSE consensus

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Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently recurs postoperatively despite treatments.
  • A standardized definition and understanding of recurrence determinants are currently lacking.
  • This gap hinders effective management and patient outcomes.

Purpose of the Study:

  • To establish a consensus-based definition of CRSwNP recurrence.
  • To identify and agree upon key prognostic factors contributing to CRSwNP recurrence.
  • To improve the clinical management of CRSwNP.

Main Methods:

  • A Delphi consensus study involving 70 multidisciplinary experts (ENT specialists and allergists).
  • Two rounds of online questionnaires based on a comprehensive literature review.
  • Consensus defined as ≥70% agreement among panelists.

Main Results:

  • Consensus was achieved on the definition of CRSwNP recurrence (87% agreement).
  • Ten key prognostic factors for recurrence were identified.
  • Top factors include nonsteroidal anti-inflammatory drug-exacerbated respiratory disease, eosinophilic CRSwNP, asthma, surgical extent, and polyp eosinophilia.

Conclusions:

  • A clear definition of CRSwNP recurrence was established, incorporating symptom changes and objective inflammatory evidence.
  • Key prognostic factors were identified, aiding in risk stratification and personalized treatment strategies.
  • This consensus provides a foundation for future research and clinical guidelines in CRSwNP management.