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Related Concept Videos

Birth Control Methods01:22

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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Intrauterine Drug Delivery Systems01:21

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Hormonal Regulation of the Menstrual Cycle01:22

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
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Related Experiment Video

Updated: Apr 30, 2026

Optimizing the Modified No-Scalpel Vasectomy Technique
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Novel male contraceptives.

Jacqueline Quinn1, John J Reynolds-Wright1

  • 1Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh.

Future Science OA
|April 29, 2026
PubMed
Summary

Novel male contraceptives are in development, including hormonal and non-hormonal methods. A large trial of a new hormonal contraceptive has finished, with results pending, while this review covers current and future options.

Area of Science:

  • Reproductive medicine and urology.
  • Contraceptive development and clinical trials.

Background:

  • Current male contraception relies on condoms, vasectomy, and withdrawal.
  • There is a need for diverse and effective male contraceptive options.

Purpose of the Study:

  • To review the current landscape of male contraceptive development.
  • To discuss novel hormonal, non-hormonal, immunological, and vas-occlusive methods.
  • To highlight potential future male contraceptive interventions.

Main Methods:

  • This is a narrative review of existing literature and ongoing research.
  • Discussion includes data from a recently concluded multinational trial of a novel hormonal contraceptive.

Main Results:

Keywords:
Male contraceptionandrogenhydrogelprogestinsegesterone acetatetestosterone

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  • A large multinational trial of a novel hormonal contraceptive has concluded; results are currently awaited.
  • The review synthesizes information on various emerging male contraceptive technologies.

    • Conclusions:

    • The field of male contraception is advancing with multiple novel approaches.
    • Further research and clinical trials are essential to bring new male contraceptives to market.