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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
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Thirty-Day Readmission After Hospitalisation for Diabetic Foot Ulcer: A Nationwide Analysis
Krishna O Sanaka1, Nandita Mitra2, David J Margolis2,3
1Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Summary
Diabetic foot ulcer hospital readmissions are high at 13.3%, driven by systemic conditions like kidney disease, not local infection. This highlights the need for comprehensive care after discharge.
Area of Science:
- Diabetology
- Vascular Surgery
- Public Health
Background:
- Diabetic foot ulcers (DFUs) are a major cause of diabetes-related hospitalizations, morbidity, and mortality.
- High hospital readmission rates for DFUs persist, but national data on patterns and causes are scarce.
Purpose of the Study:
- To analyze 30-day all-cause readmission rates for diabetic foot ulcer hospitalizations in the US.
- To identify factors associated with readmission and compare index vs. readmission hospitalizations.
Main Methods:
- Retrospective cohort study using the 2022 Nationwide Readmissions Database.
- Identified adult hospitalizations with DFU diagnosis codes.
- Survey-weighted analyses for national estimates.
Main Results:
- An estimated 13.3% of 234,797 DFU hospitalizations resulted in 30-day readmission, surpassing the 8.2% national average.
- Readmitted patients had higher rates of kidney disease, cardiovascular disease, and mental health conditions.
- Kidney disease, cardiovascular comorbidities, tobacco use, drug use disorder, and bipolar disorder increased readmission odds; infections and procedures decreased them.
Conclusions:
- Early readmissions for diabetic foot ulcers are primarily linked to systemic medical instability, not recurrent local infection.
- Multidisciplinary inpatient and post-discharge care strategies are crucial for managing DFU readmissions.
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