The carboxypeptidase-dependent inactivation of thymidylate synthetase

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Biochemistry·2001

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Invertase storage stability and sucrose hydrolysis in solids as affected by water activity and glass transition.

Journal of agricultural and food chemistry·1999

F-actin-dependent activation of NADPH oxidase 5 by the vacuolar-type ATPase.

The Journal of biological chemistry·2026

Enhanced SIRT3 activity potentiates germinal center epigenetic modulation through α-ketoglutarate.

The Journal of biological chemistry·2026

Mammalian DNA methyltransferases in DNA methylation and imprinted gene expression in extraembryonic ectoderm of post-implantation embryos.

The Journal of biological chemistry·2026

Genetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase target in STK11-mutant lung cancer.

The Journal of biological chemistry·2026

GATA3-driven CDC20 activation facilitates tumor growth and metastasis through suppressing Bax/Bcl-2 ratio and boosting EMT process in neuroblastoma.

The Journal of biological chemistry·2026

5-Iodotubercidin inhibits Epithelial to Mesenchymal Transition by inhibiting IKK/NFκB-dependent gene expression.

The Journal of biological chemistry·2026

Sucnr1 Mediates Leukocyte-Endothelial Cell Interactions Induced by Tnfα.

International journal of molecular sciences·2026

Protocol for controlled gas-phase oxygen In-leakage in anaerobic bioreactors.

MethodsX·2026

Temporal regulation of miRNA 92a and miRNA 279d on PaEno1 expression and dynamic responses of metal-stress-related genes to cadmium exposure in Propsilocerus akamusi (Diptera: Chironomidae) larvae.

Bulletin of entomological research·2026

GUTchetp: integrated prediction of gut microbial biotransformation profiles using ensemble monolingual and multilingual neural machine translation and enzyme class consistency-reaction similarity.

Gut microbes·2026

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Journal of environmental management·2026

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Production & manufacturing research·2026

Related Experiment Videos

The carboxypeptidase-dependent inactivation of thymidylate synthetase

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Invertase storage stability and sucrose hydrolysis in solids as affected by water activity and glass transition.

F-actin-dependent activation of NADPH oxidase 5 by the vacuolar-type ATPase.

Enhanced SIRT3 activity potentiates germinal center epigenetic modulation through α-ketoglutarate.

Mammalian DNA methyltransferases in DNA methylation and imprinted gene expression in extraembryonic ectoderm of post-implantation embryos.

Genetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase target in STK11-mutant lung cancer.

GATA3-driven CDC20 activation facilitates tumor growth and metastasis through suppressing Bax/Bcl-2 ratio and boosting EMT process in neuroblastoma.

5-Iodotubercidin inhibits Epithelial to Mesenchymal Transition by inhibiting IKK/NFκB-dependent gene expression.

Sucnr1 Mediates Leukocyte-Endothelial Cell Interactions Induced by Tnfα.

Protocol for controlled gas-phase oxygen In-leakage in anaerobic bioreactors.

Temporal regulation of miRNA 92a and miRNA 279d on PaEno1 expression and dynamic responses of metal-stress-related genes to cadmium exposure in Propsilocerus akamusi (Diptera: Chironomidae) larvae.

GUTchetp: integrated prediction of gut microbial biotransformation profiles using ensemble monolingual and multilingual neural machine translation and enzyme class consistency-reaction similarity.

Advancing environmental resilience to wildfires: A high-performance stochastic simulation approach for real-time risk assessment and spread prediction.

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The carboxypeptidase-dependent inactivation of thymidylate synthetase

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