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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: Apr 30, 2026

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model
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Advances in Collagen Extraction and Biomaterial Design for Drug Delivery Applications: A Comprehensive Review.

Harsh Bhati1, Juhi Saraswat2, Amit Kumar Verma1

  • 1Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.

ACS Biomaterials Science & Engineering
|April 29, 2026
PubMed
Summary

Fish-derived collagen offers a sustainable biomaterial for drug delivery systems. This review covers collagen structure, extraction, fabrication, and applications in treating neurodegenerative disorders, cancer, and wound healing.

Keywords:
Collagenbiomaterialsbiomedical applicationsdrug delivery systems (DDS)fish sourcesneurodegenerative diseasessustainablewound healing

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Drug Delivery

Background:

  • Collagen is a versatile biopolymer for biomedical applications due to its biodegradability, biocompatibility, and safety.
  • Mammalian collagen sources are conventional, but fish-derived collagen presents a sustainable and economical alternative.

Purpose of the Study:

  • To review the structure, types, and extraction methods of collagen, particularly fish-derived collagen.
  • To explore fabrication strategies for collagen-based biomaterials for drug delivery.
  • To examine the biomedical applications of these materials in various diseases.

Main Methods:

  • Literature review of collagen structure, properties, and extraction techniques (acid-based, enzymatic, green chemistry).
  • Analysis of fabrication methods for collagen biomaterials (nanoparticles, films, hydrogels, sponges).
  • Examination of drug delivery applications in neurodegenerative disorders, cancer, and wound healing.

Main Results:

  • Fish-derived collagen is a viable, sustainable alternative to mammalian sources.
  • Various fabrication techniques yield diverse collagen biomaterials for controlled drug release.
  • Collagen-based systems show promise for targeted therapy in complex diseases.

Conclusions:

  • Collagen, especially from fish, is a highly versatile biomaterial for advanced drug delivery systems.
  • Collagen biomaterials offer significant therapeutic potential across multiple medical fields.
  • Further research into fish-derived collagen can enhance sustainable biomedical solutions.