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Updated: Apr 30, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
An informatics-based data-led prioritization strategy to facilitate objective and equitable care for an ethnically
Panagiotis Pavlou1,2, Khuram Chaudhry2, Ollie French3
1King's College Diabetes Department, School of Cardiovascular and Metabolic Medicine, King's College London, London, UK.
Abstract:
BackgroundEthnicity and socioeconomic factors contribute to higher morbidity and mortality in people with type 1 diabetes (pwT1D), partly due to reduced access to specialised care and technology. Objectively prioritising high-risk individuals in resource-limited settings is challenging. Data-led prioritisation (DLP) uses health informatics to stratify pwT1D based on new-onset risk factors since their last review. This may help overcome implicit bias, structural racism, and care barriers. However, data on its use in pwT1D are limited.MethodsIn this proof-of-concept study, DLP was implemented from July to September 2023 in a university hospital serving an ethnically diverse population. Clinical and demographic data were collected from 697 adults with T1D (50.5% female, 23.5% non-White, 37% from poor socioeconomic backgrounds). DLP identified 76 individuals (10.9%) as highest risk.ResultsNon-White patients were more likely to be in the highest-risk group (30/164, 18.3%) than White patients (35/372, 9.4%), p=0.004. Those from the most deprived socioeconomic backgrounds were also more likely to be high-risk (40/256, 15.7%) vs others (36/433, 8.3%), p=0.008.ConclusionDLP may enable objective risk stratification in pwT1D and could help reduce bias linked to ethnicity and deprivation. Further large-scale research is warranted to demonstrate the use of such systems in diabetes care.
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