Related Experiment Video
Updated: Apr 30, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.4K
Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications
Brian T Helfand1,2,3, Zhuqing Shi2, Ashley J Mulford4
1Division of Urology, Endeavor Health, Evanston, Illinois, USA.
The Prostate
|April 29, 2026
Summary
Prostate cancer (PCa) diagnosis and genetic factors increase the risk of chronic non-urological complications in survivors. Understanding these risks is crucial for improving long-term health outcomes for PCa patients.
Area of Science:
- Oncology
- Genetics
- Epidemiology
Background:
- Chronic non-urological complications are frequent in prostate cancer (PCa) survivors.
- The full spectrum, impact, and genetic underpinnings of these complications are not well understood.
Purpose of the Study:
- To investigate the association between PCa diagnosis and 15 common non-urological complications.
- To assess the role of genetic susceptibility, using polygenic risk scores (PRS), in these complications.
Main Methods:
- Utilized the UK Biobank (UKB) cohort (N=219,133) with incident PCa cases.
- Employed cause-specific Cox proportional-hazards models with time-updated PCa status.
- Examined associations between PCa, metastatic PCa (mPCa), and PRS with non-urological complications.
Main Results:
- Seven complications, including osteoporosis and depression, showed increased risk post-PCa diagnosis.
- Risks were significantly higher for metastatic PCa (mPCa) compared to non-metastatic PCa.
- Higher disease-specific polygenic risk scores (PRS) further elevated the risk for ten complications, notably osteoporosis in mPCa patients.
Conclusions:
- Both PCa diagnosis and inherited genetic susceptibility play a role in the increased risk of chronic non-urological complications.
- These findings highlight the complex interplay between cancer, genetics, and long-term health in survivors.
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