Replacement-Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions

Area of Science:

• Gerontology and regenerative medicine
• Biotechnology and bioengineering
• Molecular and cellular biology

Background:

• Aging interventions using biological and synthetic replacements can reverse age-related damage.
• These approaches hold potential for extending healthy lifespan beyond conventional therapies.
• Multi-targeted damage removal at molecular, organellar, and cellular levels is a key focus.

Purpose of the Study:

• To discuss recent insights, unmet needs, and emerging trajectories in replacement-based aging interventions.
• To prioritize challenges, opportunities, and future directions for preventive replacement and bioengineering.
• To propose a roadmap for integrating replacement and damage-removal therapeutics for whole-body rejuvenation.

Main Methods:

• Perspective review of current research and clinical development in replacement-based aging interventions.
• Discussion of insights from the first workshop on replacement as an aging intervention at the Aging Research & Drug Discovery 2025 conference.
• Identification of key challenges and opportunities for advancing the field.

Main Results:

• Replacement-based interventions show potential for simultaneous reversal of multiple age-related damages.
• Bioengineering technologies are crucial for inducing systemic and sustained rejuvenation.
• Synergistic strategies combining replacement and damage-removal are emerging.

Conclusions:

• A roadmap is proposed to guide research and innovation in replacement-based aging therapies.
• Integration of replacement and next-generation damage-removal therapeutics can modulate aging.
• These strategies aim to restore biological function and extend healthy lifespan.