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Related Experiment Video

Updated: May 1, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Biosimilars for chronic plaque psoriasis: a 2026 update.

Martina Maurelli1, Andrea Danese1, Paolo Gisondi1

  • 1Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Expert Review of Clinical Pharmacology
|April 29, 2026
PubMed
Summary

Biosimilars offer a cost-effective way to increase access to biologic treatments for moderate-to-severe psoriasis. Evidence shows they are as effective and safe as reference biologics, supporting their use as first-line options.

Keywords:
Plaque psoriasisbiologicsbiosimilarspharmacoeconomysystemic treatment

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Area of Science:

  • Dermatology
  • Pharmacoeconomics
  • Biotechnology

Background:

  • Biologic therapies are crucial for moderate-to-severe psoriasis but face challenges with cost and accessibility.
  • Biosimilars represent a strategy to overcome these limitations and improve patient access.

Purpose of the Study:

  • To review current evidence on approved psoriasis biosimilars, including efficacy, safety, interchangeability, and economic impact.
  • To assess the role of biosimilars in improving access to biologic treatments for psoriasis.

Main Methods:

  • Narrative review of literature published between January 2015 and January 2026.
  • Searches conducted in PubMed/MEDLINE and Embase for clinical trials, real-world studies, and pharmacoeconomic analyses.

Main Results:

  • Biosimilars demonstrated high similarity to reference biologics with no clinically meaningful differences in efficacy, safety, or immunogenicity.
  • Pharmacoeconomic studies confirmed significant cost savings and reduced cost-per-responder rates.
  • Evidence supports broader and earlier access to biologic therapy through biosimilar utilization.

Conclusions:

  • Biosimilars are effective, safe, and cost-saving alternatives to reference biologics for psoriasis.
  • Consideration of biosimilars as first-line biologic options can improve treatment access and health system sustainability.