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Updated: May 1, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Induced FeCl3-Promoted Dehydroxypropylative Selenylation of Acyclic Alcohols
Guo-Min Shen1, Hong Zhang1, Yun-Bing Zhou1
1College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Abstract:
A visible-light-induced, FeCl3-promoted dehydroxypropylative selenylation of tertiary acyclic alcohols with diselenides has been developed for constructing unsymmetrical monoselenides. This protocol enables direct C-C bond cleavage and concomitant C-Se bond formation without the need for an additional photocatalyst. The reaction exhibits a broad substrate scope across various diselenides and alcohols and is amenable to gram-scale synthesis. Mechanistic studies support a radical pathway initiated through ligand-to-metal charge transfer (LMCT) upon light irradiation.
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