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Current practice in reporting internal dosimetry for [177Lu]Lu-DOTATATE therapy: a systematic review
Oleksandra V Ivashchenko1, Jim O'Doherty2, Teresa Pérez García-Estañ3
1Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, the Netherlands.
Summary
Standardized dosimetry reporting for radiopharmaceutical therapies like [177Lu]Lu-DOTATATE is crucial. However, a review found many studies lack sufficient detail for reproducible dosimetry calculations, highlighting a need for improved reporting standards.
Area of Science:
- Medical Physics
- Nuclear Medicine
- Radiopharmaceutical Therapy
Background:
- Standardization of dosimetry reporting in radiopharmaceutical therapies is essential for reproducibility.
- The European Association of Nuclear Medicine (EANM) provides guidance on minimum reporting requirements.
- The EFOMP's SIG_FRID Focus Group assessed reporting in [177Lu]Lu-DOTATATE therapy studies.
Purpose of the Study:
- To evaluate the completeness of dosimetry data reporting in published [177Lu]Lu-DOTATATE therapy studies.
- To assess compliance with EANM Dosimetry Reporting Guidance.
- To identify trends in the quality of dosimetry reporting.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Identification of articles on [177Lu]Lu-DOTATATE therapy published up to December 31, 2024.
- Evaluation using a checklist based on EANM guidance and recent developments.
Main Results:
- 57 out of 144 identified articles met inclusion criteria.
- High compliance for imaging equipment (83%), image processing (82%), and absorbed dose (100%).
- Poor reporting in phantom/calibration measurements (59%), radionuclide calibrator info (18%), and time-integrated activity coefficients (29%). Only 25% fully complied with EANM guidance.
Conclusions:
- EANM dosimetry reporting guidelines are not fully implemented in [177Lu]Lu-DOTATATE studies.
- While data acquisition and imaging are well-reported, dosimetric calculation details are often incomplete.
- Further development of quality criteria is needed for reproducible and comparable dosimetry studies.
