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Arterial Pouch Microsurgical Bifurcation Aneurysm Model in the Rabbit
Published on: May 14, 2020
Formation and rupture of intracranial aneurysms with blebs: a discriminant study using anatomical and phantom models
Hang Yi1, Zifeng Yang1, Luke C Bramlage2,3
1Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH, USA.
Background:
Intracranial aneurysms (IAs) with bleb(s) carry a higher risk of rupture. This study aimed to investigate the hemodynamic factors driving bleb formation and subsequent IA rupture using anatomical and phantom models across various bleb scenarios.
Methods:
Anatomical models of 45 IAs with 67 bleb scenarios were reconstructed from 3D rotational angiographies. To study the pre-bleb state, phantom parental models were created by virtually removing the blebs. Hemodynamic characteristics were then evaluated using validated computational methods under physiological pulsatile flow.
Results:
Critical hemodynamic indicators illustrate that higher wall shear stress (WSS) was linked to IA rupture at anterior cerebral artery (ACA) bifurcation (p < 0.05), while relatively low WSS was associated with IA rupture on the internal carotid artery (ICA) (p < 0.05). Additionally, bleb initiation is significantly driven by high surface-averaged WSS (p < 0.05) and WSS gradient (p < 0.05) with lower maximum oscillatory shear index (p < 0.05).
Conclusions:
Blebs most likely form near the edge of the original impacted region rather than its center. The specific hemodynamic parameters predicting IA rupture with blebs are highly location-dependent.
