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Updated: May 1, 2026
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Pattern of Progression of Oral Potentially Malignant Disorders From Real-World Data: A 24-Year Study
Subin Surendran1, Sumsum P Sunny2, Preethi M Chathoth1
1Department of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Background:
Oral potentially malignant disorder (OPMD) prognostication is limited by uncertainty of which lesions will progress and the aggressiveness of lesion progression. We defined patterns and kinetics of progression in a large cohort of OPMD subjected to serial clinical and histologic examinations.
Methods:
This 24-year study evaluated the pattern of disease progression in 668 patients with 1313 OPMDs.
Results:
The disease progression pattern was grouped as (a) non-progressive (82.5%), (b) progressive, where initial low-grade dysplasia advanced to high-grade dysplasia in subsequent lesions (5.8%), and (c) transformed, where dysplastic lesions transformed into squamous cell carcinoma (11.7%). Progression showed aggressive (< 2 years) and indolent (> 2 years) patterns. An aggressive course occurred in 48.3% of progressive and 57.6% of transformed lesions. Progression was associated with high-grade lesions, floor of mouth and palate subsites, and tobacco and alcohol use.
Conclusions:
The data from this study may be used to develop a risk-stratified approach for OPMD management.
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