Variations in Eclampsia Risk Across Asian Origin Groups in the United States.

Area of Science:

• Reproductive Health
• Maternal Morbidity
• Epidemiology

Background:

• Eclampsia is a major cause of severe maternal morbidity in the U.S.
• While overall severe maternal morbidity rates are similar for Asian and non-Hispanic White populations, eclampsia risk variations within Asian subgroups are understudied.

Purpose of the Study:

• To investigate eclampsia risk variations across different Asian origin groups.
• To examine the impact of nativity (foreign-born vs. US-born) on eclampsia risk within these populations.

Main Methods:

• Cross-sectional study utilizing 2018-2021 Natality Files data.
• Compared eclampsia incidence and adjusted odds ratios (aOR) based on maternal race (non-Hispanic White, Asian) and nativity.
• Foreign-born non-Hispanic White individuals served as the reference group.

Main Results:

• Eclampsia incidence per 10,000 births was higher for US-born Asians (49.6) than foreign-born Asians (20.9) and US-born non-Hispanic Whites (26.7).
• Among Asian groups, US-born Japanese (256.0) and US-born Filipinos (120.6) showed the highest incidence.
• US-born Filipinos had the highest adjusted odds of eclampsia (aOR: 9.36) compared to the reference group.

Conclusions:

• Eclampsia risk is not uniform across all Asian populations.
• Nativity plays a critical role, with US-born individuals from specific Asian origin groups exhibiting substantially elevated risks.
• Findings highlight the need for targeted interventions and further research into the determinants of eclampsia risk among diverse Asian subgroups.