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Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
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Parkinson Disease ll: Pathophysiology01:24

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

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Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Related Experiment Video

Updated: May 1, 2026

Postural Organization of Gait Initiation for Biomechanical Analysis Using Force Platform Recordings
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Postural Control Determinants of Gait Dysfunction in Huntington's Disease.

Franchino Porciuncula1, Paula Wasserman2, Karen S Marder2,3

  • 1Sargent College of Health & Rehabilitation Sciences, Boston University, MA, USA.

Neurorehabilitation and Neural Repair
|April 30, 2026
PubMed
Summary

Postural control and gait deficits begin early in Huntington's disease (HD), worsening with disease progression. These postural impairments significantly contribute to gait dysfunction, suggesting the need for early intervention.

Keywords:
Huntington’s diseaselocomotionpostureprecision rehabilitationwearable sensors

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Area of Science:

  • Neurology
  • Biomechanical Engineering
  • Movement Science

Background:

  • Gait dysfunction is a significant challenge in Huntington's disease (HD).
  • The relationship between postural control deficits and gait problems across the HD spectrum (pre-manifest HD [pHD] to manifest HD [mHD]) is not well understood.

Purpose of the Study:

  • To investigate the interplay between posture and gait in individuals with HD.
  • To quantify postural control and gait deficits across the HD spectrum.
  • To determine the contribution of postural control impairments to gait dysfunction in HD.

Main Methods:

  • Utilized wearable sensors to measure postural control (Jerk, Total Sway Area) under sensory-challenging conditions.
  • Assessed gait quality (e.g., stride length, cadence, %stance) and stride-to-stride variability at self-selected pace.
  • Compared outcomes between healthy controls (n=10), pHD (n=17), and mHD (n=11) groups, and used regression analyses to link postural control to gait deficits.

Main Results:

  • Both postural control and gait impairments were observed in pHD and significantly worsened in mHD (P < .05).
  • Postural control deficits accounted for 14% to 39% of the variance in gait dysfunction, including gait quality and variability measures (P < .05).

Conclusions:

  • Postural control and gait deficits emerge in the pre-manifest stage of HD and progress with the disease, underscoring the importance of early interventions.
  • Postural control impairments are a substantial contributor to gait deficits in HD, not merely a coincidental finding.
  • Further research is needed to integrate these posture-gait findings into clinical gait rehabilitation strategies for HD.