Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

20
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
20
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

611
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
611
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

55
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
55

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early versus Late starting of Direct Oral Anticoagulants after breakthrough ischemic stroke: A Target Trial Analysis from the ASPERA-R Study.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

The Latest Global Stroke Fact Sheet 1990-2023: Global Burden of Disease Study.

Neuroepidemiology·2026
Same author

Continuation vs Switching Direct Oral Anticoagulant Therapy After Breakthrough Stroke.

JAMA network open·2026
Same author

Competing Stroke Etiologies and Outcomes After Breakthrough Ischemic Stroke on Oral Anticoagulants in Patients With Atrial Fibrillation.

Neurology·2026
Same author

Global burden of cerebral small vessel disease determined from large MRI studies: A systematic review and meta-analysis.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

Sex Differences in Outcomes After Breakthrough Ischemic Stroke on Oral Anticoagulants for Atrial Fibrillation: An ASPERA-R Inverse Probability Weighted Analysis.

Journal of the American Heart Association·2026

Related Experiment Video

Updated: May 1, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

2.1K

Recognizing, managing, and preventing cognitive sequelae after stroke. A narrative review.

Leonardo Pantoni1,2, Slaven Pikija3,4, Tuyen Van Nguyen5

  • 1Neuroscience Research Center, Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, Via Giovanni Battista Grassi 74, 20157 Milan (MI), Italy.

Cerebral Circulation - Cognition and Behavior
|April 30, 2026
PubMed
Summary

Post-stroke cognitive impairment (PSCI) affects many survivors, impacting quality of life. Early diagnosis and management, focusing on vascular risk factors and rehabilitation, are crucial for improving outcomes in stroke patients.

Keywords:
BiomarkersCerebral small vessel diseasePathophysiologyPost-stroke cognitive impairmentPost-stroke dementiaPreventionVascular cognitive impairment

More Related Videos

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

9.4K

Related Experiment Videos

Last Updated: May 1, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

2.1K
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

9.4K

Area of Science:

  • Neuroscience
  • Neurology
  • Public Health

Background:

  • Post-stroke cognitive impairment (PSCI) affects up to one-third of stroke survivors, significantly impacting long-term disability and quality of life.
  • Its complex nature arises from acute injury combined with chronic vascular issues, inflammation, and potential neurodegeneration.
  • Clinical presentations are diverse, influenced by lesion location, commonly affecting executive functions and attention.

Purpose of the Study:

  • To synthesize current evidence on the mechanisms, presentation, diagnosis, and management of PSCI.
  • To highlight priorities for harmonized care pathways and integrating cognitive health into routine stroke care.
  • To review emerging diagnostic adjuncts and treatment strategies for PSCI.

Main Methods:

  • This narrative review synthesizes existing scientific literature on PSCI.
  • It examines diagnostic strategies including cognitive screening, neuropsychological assessment, and neuroimaging (CT and MRI).
  • The review considers emerging tools like fluid biomarkers and digital monitoring, alongside current treatment and prevention approaches.

Main Results:

  • Diagnosis is challenging due to overlapping pathologies; a stepwise approach is recommended.
  • Treatment options are limited, with non-pharmacological interventions like cognitive rehabilitation and physical activity being central.
  • Prevention strategies emphasize vascular risk factor control, lifestyle changes, and cognitive reserve enhancement.

Conclusions:

  • Harmonized care pathways and routine integration of cognitive health assessments are essential for PSCI management.
  • Further high-quality evidence is needed for PSCI-specific interventions.
  • Focusing on prevention through vascular risk management and lifestyle modifications is paramount.