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Updated: May 1, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Electrochemically driven strain-release dearomative (3 + 2) cyclization for the synthesis of

Yanren Zhu1, Enfan Pu1, Shaoxiong Yang1

  • 1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, School of Chemical Science and Technology, School of Pharmacy, Yunnan University Kunming 650500 China zhanghb@ynu.edu.cn chenjb@ynu.edu.cn.

Chemical Science
|April 30, 2026
PubMed
Summary

Researchers developed an electrochemical method to synthesize complex spiroindolines from bicyclo[1.1.0]butane-substituted indoles. This efficient strategy creates novel polycyclic compounds with multiple stereocenters, valuable for medicinal chemistry.

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