Detecting and forecasting tipping points from sample variance alone

Naoki Masuda1,2,3

  • 1Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.

PNAS Nexus
|April 30, 2026
PubMed
Summary

We developed TIPMOC, a new method to predict tipping points in complex systems using only variance. TIPMOC accurately detects approaching bifurcations and estimates their timing, improving upon traditional early warning signals.

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