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Biomarkers for Monitoring R-CHOP-associated Cardiotoxicity in Patients with Non-hodgkin Lymphoma
G R Gimatdinova1, O E Danilova2, I L Davydkin3
1Department of Hospital Therapy with courses in Hematology and Transfusiology, Hematologist at the Department of Hematology and Chemotherapy No. 2 with the Bone Marrow and Hematopoietic Stem Cell Transplantation Unit at Samara Medical University, Samara, Russia.
Early detection of cardiotoxicity in non-Hodgkin lymphoma patients is possible using corrected QT interval, left ventricular strain, and NT-proBNP levels. These biomarkers aid in timely treatment adjustments for hematologic malignancies.
Area of Science:
- Oncology
- Cardiology
- Biomarker Discovery
Background:
- Antineoplastic therapies, particularly anthracyclines in indolent non-Hodgkin lymphoma, pose a significant risk of cardiotoxicity.
- Hematologic malignancies require careful monitoring for treatment-related toxicities.
- Cardiotoxicity is a critical concern in patients undergoing chemotherapy.
Purpose of the Study:
- To identify early, sensitive biomarkers for detecting treatment-related cardiotoxicity.
- To evaluate the prognostic utility of specific laboratory and instrumental markers.
- To aid in the early detection of cardiovascular damage during chemotherapy.
Main Methods:
- A case-control study involving 72 patients with follicular B-cell non-Hodgkin lymphoma.
- Administration of six cycles of R-CHOP immunochemotherapy.
- Monitoring of corrected QT interval (QTc), left ventricular global longitudinal strain, and N-terminal pro-B-type Natriuretic Peptide (NT-proBNP).
Main Results:
- Prolongation of the corrected QT interval (QTc) was a sensitive indicator of cardiotoxicity.
- Reduction in left ventricular global longitudinal strain identified early cardiovascular changes.
- Elevated N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) levels correlated with cardiotoxicity.
- Prognostic models were developed to predict cardiotoxicity at 3 and 6 months.
Conclusions:
- The identified biomarkers (QTc, LV strain, NT-proBNP) are consistent with existing literature.
- These markers demonstrate prognostic utility for early cardiotoxicity detection.
- Routine monitoring of these biomarkers can optimize clinical management and allow for timely therapeutic adjustments.
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