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Updated: May 1, 2026
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Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
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A pH/Enzyme Dual-Responsive Dropping Pill System for Colon-Targeted Delivery of Naringin
Xintao Qiu1, Yuanyuan Chen2, Jing Shu1
1School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, P.R. China.
Current Drug Delivery
|April 30, 2026
Summary
A new colon-targeted naringin pill was developed for ulcerative colitis. This pH/enzyme dual-responsive system ensures targeted delivery, improving treatment efficacy and reducing side effects.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Gastroenterology
Background:
- Ulcerative colitis (UC) necessitates targeted therapies to improve efficacy and minimize systemic side effects.
- Naringin, a natural anti-inflammatory flavonoid, has low bioavailability and nonspecific release, limiting its therapeutic potential for UC.
- Developing a colon-targeted delivery system for naringin is crucial for effective UC treatment.
Purpose of the Study:
- To develop and optimize a colon-targeted delivery system for naringin.
- To address the limitations of naringin's bioavailability and nonspecific release for ulcerative colitis treatment.
- To create a pH/enzyme dual-responsive system for enhanced colon-specific drug delivery.
Main Methods:
- Pill core preparation using melt-dropping method and orthogonal experimental design.
- Optimization of pH/enzyme dual-responsive coating via Box-Behnken response surface methodology.
- In vitro release evaluation in a gradient pH model and enzymatic tolerance tests.
Main Results:
- Optimal core conditions achieved 33% drug loading and excellent sphericity.
- Optimized coating formulation demonstrated efficient drug retention in gastric/intestinal conditions.
- The system showed significant drug release (75-78%) in colonic fluid within 10 hours, fitting Weibull model kinetics.
Conclusions:
- The developed pH/enzyme dual-responsive system ensures colon-specific delivery, overcoming limitations of single-trigger systems.
- This formulation holds potential for localized treatment of ulcerative colitis.
- Further in vivo studies are required to confirm the therapeutic efficacy of this colon-targeted naringin delivery system.
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