Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review)

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• c-Myc is a proto-oncogenic transcription factor crucial for tumor cell proliferation, cell cycle regulation, DNA repair, and metabolic reprogramming.
• It significantly influences targeted drug efficacy and tumor drug resistance in cancer therapeutics.

Purpose of the Study:

• To comprehensively review the structural characteristics of c-Myc.
• To summarize its roles and molecular mechanisms in various malignancies.
• To outline current c-Myc-targeted therapies, clinical trials, challenges, and future research directions.

Main Methods:

• Literature review and synthesis of existing research on c-Myc.
• Analysis of c-Myc's structural features and functional roles in cancer.
• Examination of current therapeutic strategies and clinical trial data.

Main Results:

• c-Myc's multifaceted roles in cancer biology, including proliferation and genomic maintenance.
• Its critical involvement in mediating drug resistance and influencing treatment outcomes.
• Identification of various therapeutic strategies targeting c-Myc and ongoing clinical investigations.

Conclusions:

• c-Myc is a key driver in tumorigenesis and a critical determinant of therapeutic response.
• Targeting c-Myc presents a promising avenue for novel precision cancer therapies.
• Further research into c-Myc mechanisms and targeted interventions is essential for advancing cancer treatment.