Related Experiment Video
Updated: May 1, 2026

Unveiling Xenobiotic Transport and Effects in Isolated Mitochondria: Insights from Respirometric and Enzymatic Assays
Published on: March 7, 2025
Triclabendazole disrupts mitochondrial electron transport in vitro
Tobias Kämpfer1,2, María Eugenia Ancarola1, Pascal Zumstein1,2
1Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.
Abstract:
Mitochondrial respiration, which relies on succinate dehydrogenase (SDH), among other factors, is essential for cellular energy metabolism. This study shows that triclabendazole and its primary metabolites inhibit SDH in mitochondria of the cestode Echinococcus multilocularis, while other benzimidazoles do not. Similar effects were observed in mitochondria from additional helminths (trematodes, nematodes) and mammalian cells. These findings indicate a shared mode of action and highlight potential safety risks associated with long-term triclabendazole treatment in mammals.
More Related Videos
14:39Cholinergic Ligand–dependent Modulation of Oxidative Phosphorylation Coupling in Digitonin-permeabilized BE(2)-C Neuroblastoma Cells
Published on: April 28, 2026
11:43A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
Published on: October 16, 2015
Related Concept Videos
Anthelminthic Agents
The Electron Transport Chain
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Drugs that Destabilize Microtubules