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Updated: May 1, 2026
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Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
Published on: November 30, 2022
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A Longitudinal Comprehensive Biospecimen and Clinical Data Repository for Cancer Early Detection: The InAdvance Study
Tia L Kauffman1, Elizabeth K O'Donnell1,2, Catherine R Marinac1,2
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Summary
The InAdvance Study collects biospecimens and health data from high-risk individuals to advance cancer early detection and interception research. This initiative aims to fill a critical gap in resources for cancer risk assessment and prevention strategies.
Area of Science:
- Oncology
- Genetics
- Epidemiology
Background:
- A significant gap exists in biobanking resources for individuals at elevated risk of cancer.
- Existing biobanks primarily focus on cancer patients or average-risk populations.
Purpose of the Study:
- To longitudinally collect biospecimens and health data from individuals with diverse cancer risk factors.
- To facilitate collaborative research in cancer early detection and interception.
- To establish a comprehensive biorepository for high-risk populations.
Main Methods:
- Enrolling participants with pre-cancerous lesions, hereditary risk, personal/family history, or exposure history.
- Including participants receiving multi-cancer early detection (MCED) tests and their families.
- Utilizing an online platform for participant engagement and standardized procedures for biospecimen collection and data compilation.
Main Results:
- As of April 2023, 1,415 participants enrolled in the InAdvance Study.
- 58% of participants completed the baseline survey.
- 58% provided a baseline blood sample.
Conclusions:
- The InAdvance Study provides a framework for research into molecular and environmental factors driving cancer development.
- Comprehensive data and biospecimen repositories are essential for improving early detection, risk stratification, and outcomes in high-risk populations.
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