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Related Concept Videos

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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A Longitudinal Comprehensive Biospecimen and Clinical Data Repository for Cancer Early Detection: The InAdvance

Tia L Kauffman1, Elizabeth K O'Donnell1, Catherine R Marinac2

  • 1Dana-Farber Cancer Institute Boston, MA United States.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
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PubMed
Summary
This summary is machine-generated.

The InAdvance Study collects biospecimens and health data from high-risk individuals to advance cancer early detection and interception research. This initiative aims to fill a critical gap in resources for cancer risk assessment and prevention strategies.

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Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • A significant gap exists in biobanking resources for individuals at elevated risk of cancer.
  • Existing biobanks primarily focus on cancer patients or average-risk populations.

Purpose of the Study:

  • To longitudinally collect biospecimens and health data from individuals with diverse cancer risk factors.
  • To facilitate collaborative research in cancer early detection and interception.
  • To establish a comprehensive biorepository for high-risk populations.

Main Methods:

  • Enrolling participants with pre-cancerous lesions, hereditary risk, personal/family history, or exposure history.
  • Including participants receiving multi-cancer early detection (MCED) tests and their families.
  • Utilizing an online platform for participant engagement and standardized procedures for biospecimen collection and data compilation.

Main Results:

  • As of April 2023, 1,415 participants enrolled in the InAdvance Study.
  • 58% of participants completed the baseline survey.
  • 58% provided a baseline blood sample.

Conclusions:

  • The InAdvance Study provides a framework for research into molecular and environmental factors driving cancer development.
  • Comprehensive data and biospecimen repositories are essential for improving early detection, risk stratification, and outcomes in high-risk populations.