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Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

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Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A

Ammar Saadoon Alishlash¹, Anis Rabbani Nourani¹, A K M Fazlur Rahman²

¹Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Pediatric Blood & Cancer

|April 30, 2026

Summary

This summary is machine-generated.

Pulmonary dysfunction in children with sickle cell disease (SCD) is linked to nocturnal hypoxemia. Abnormal spirometry may indicate sleep-related breathing issues, aiding early intervention for better outcomes.

Keywords:

hemoglobin lung function test nocturnal hypoxia obstructive sleep apnea polysomnography spirometry

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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

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Published on: November 5, 2019

Area of Science:

Pediatric Pulmonology
Sleep Medicine
Hematology

Background:

Children with sickle cell disease (SCD) frequently experience pulmonary dysfunction and sleep abnormalities.
These conditions are linked to poorer clinical outcomes in pediatric SCD patients.
The relationship between spirometry findings and polysomnography (PSG) results in this population is not well understood.

Purpose of the Study:

To investigate the association between spirometry abnormalities and polysomnography (PSG) findings, specifically markers of nocturnal hypoxemia, in children with SCD.

Main Methods:

A multicenter, cross-sectional study involving 109 children with SCD.
Participants underwent both spirometry and PSG at accredited pediatric pulmonary centers.
Correlation and multivariable regression models were used to analyze associations between spirometry indices and PSG hypoxemia markers.

Main Results:

Abnormal spirometry was common: 26% had reduced forced expiratory volume in 1 second (FEV1), and 21% had reduced forced vital capacity (FVC).
Over 50% showed an elevated obstructive apnea-hypopnea index, and 31% experienced nocturnal hypoxemia.
Lower FEV1 and FVC correlated with increased odds of nocturnal hypoxemia; FEV1% remained independently associated with mean oxygen saturation (SpO2).

Conclusions:

Impaired lung function, indicated by abnormal spirometry, correlates with nocturnal hypoxemia in pediatric SCD.
Spirometry results may serve as a potential marker for nocturnal hypoxemia, suggesting targeted interventions.
Further research is needed to confirm these findings and explore if improving pulmonary function mitigates sleep complications in pediatric SCD.