Related Experiment Video
Updated: May 1, 2026
07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
5.6K
Resistant Starch as a Functional Nutrient to Control Cardiometabolic Risk Factors in Humans: An Integrative Review
Isabela Ribeiro Grangeira Tavares1, Eduardo Éric Almeida do Carmo1, Thiago da Silveira Alvares2,3
1Food Analysis and Nutritional Biochemistry Laboratory, Food and Nutrition Institute, Multidisciplinary Center UFRJ-Macaé, Macaé, RJ, Brazil.
Current Nutrition Reports
|April 30, 2026
Summary
Resistant starch (RS) intake, especially RS2 and RS3, improves glycemic control and lipid profiles. Further research is needed to confirm its cardiometabolic benefits and mechanisms.
Area of Science:
- Nutritional Science
- Metabolic Health
- Cardiovascular Research
Background:
- Resistant starch (RS) is recognized for potential metabolic benefits.
- Existing clinical evidence on RS efficacy is inconsistent regarding type and dosage.
- Adults and older adults are the focus for metabolic and cardiovascular health improvements.
Purpose of the Study:
- To review and synthesize evidence on RS consumption effects in dietary interventions.
- To evaluate impacts on metabolic and cardiovascular parameters in adults and older adults.
- To address inconsistencies in current clinical findings on RS.
Main Methods:
- Integrative review of dietary intervention studies.
- Analysis of effects on insulin sensitivity, lipid profile, and inflammatory markers.
- Examination of RS types (RS2, RS3) and dosages.
Main Results:
- RS intake significantly reduced postprandial glucose, insulin, and HOMA-IR.
- Improvements observed in total cholesterol, LDL-C, and triglycerides.
- Modest decreases in blood pressure and central adiposity linked to SCFA, GLP-1, and PYY.
Conclusions:
- Resistant starch shows potential for cardiometabolic modulation, especially glycemic and lipid control.
- Methodological heterogeneity and short trial durations limit current conclusions.
- Longer, standardized trials are necessary to confirm efficacy and elucidate mechanisms.
Related Concept Videos
01:19Overview of Carbohydrate Metabolism
4.5K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
4.5K
01:36Carbohydrate Metabolism
10.4K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.4K
01:34Introduction to Carbohydrates
16.3K
Carbohydrates, proteins, and fats are the primary macronutrients in the human diet. However, carbohydrates are the most favored source of energy in the body. They can be found in a wide variety of foods, including whole grains, fruit, and vegetables, in various forms, such as sugars, starch, and dietary fiber. Based on their structure, carbohydrates are classified into three main classes— monosaccharides, disaccharides, and polysaccharides. The body's cells can only utilize simple...
16.3K
01:26Atherosclerosis III: Management
741
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
741
01:19Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
953
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
953
01:15Carbohydrates: Dietary Sources and Requirements
2.5K
Carbohydrates are predominantly obtained from plant sources. With the exception of lactose found in milk and insignificant glycogen amounts in meat, most consumed carbohydrates have plant origins. Monosaccharides and disaccharides, or sugars, can be sourced from fruits, honey, milk, sugar cane, and sugar beets. Grains and vegetables are rich in the polysaccharide starch. Two types of polysaccharides provide fiber: cellulose, which is abundant in many vegetables, forms undigestible roughage or...
2.5K