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A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination
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C-Peptide Provides Critical Contextual Insight Into Elevated Glucose Values During Progression to Type 1 Diabetes
Emily K Sims1, Jay S Skyler2, Laura M Jacobsen3
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN.
Diabetes Care
|April 30, 2026
Summary
Measuring C-peptide levels can improve type 1 diabetes prediction and treatment monitoring. This biomarker offers better context for glycemia, aiding in early detection and therapy response assessment.
Area of Science:
- Endocrinology
- Immunology
- Metabolic Diseases
Background:
- Increasing development of disease-modifying therapies for presymptomatic type 1 diabetes.
- Current staging relies on islet autoantibodies and glycemic status.
- Need for improved prediction and monitoring of type 1 diabetes progression.
Purpose of the Study:
- To advocate for the inclusion of C-peptide measurements in type 1 diabetes staging.
- To highlight C-peptide's potential for enhanced disease prediction and therapy monitoring.
Main Methods:
- Review and analysis of existing type 1 diabetes staging criteria.
- Discussion of C-peptide's utility in providing context for glycemic status.
- Exploration of C-peptide's role in identifying responses to disease-modifying therapies.
Main Results:
- C-peptide offers better prediction of progression to clinical type 1 diabetes.
- C-peptide provides specificity for type 1 diabetes features, reducing confounding factors like age and insulin resistance.
- C-peptide can rapidly identify responses to disease-modifying therapies.
Conclusions:
- Incorporating C-peptide into staging systems can refine type 1 diabetes diagnosis.
- C-peptide measurement is crucial for effective disease modification strategies.
- Translational research on C-peptide is key for future type 1 diabetes management.
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