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Copper-Based Metal Organic Frameworks for Controlled Curcumin Delivery and Antimicrobial Activity.

Md Ashikur Rahman1, Na Sun1, Mohashin Kabir1

  • 1College of Textiles and Clothing, Qingdao University, Qingdao 266071, China.

ACS Applied Bio Materials
|April 30, 2026
PubMed
Summary

Curcumin-loaded HKUST-1, a copper-based metal-organic framework, demonstrates potent antioxidant and antibacterial properties. The 1:1 ratio showed optimal loading and efficacy for biomedical applications.

Keywords:
HKUST-1antimicrobialbiocompatibilitycopper-based MOFscurcumincytotoxicity

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Metal-organic frameworks (MOFs) offer tunable properties for drug delivery.
  • Curcumin, a natural compound, possesses antioxidant and anti-inflammatory benefits.
  • Developing effective drug delivery systems for curcumin is crucial for its therapeutic potential.

Purpose of the Study:

  • To synthesize and characterize curcumin-loaded HKUST-1 (a copper-based MOF).
  • To evaluate its potential as a multifunctional platform for biomedical applications.
  • To investigate the effect of curcumin loading ratios on material properties and biological activity.

Main Methods:

  • Solvothermal synthesis of HKUST-1.
  • Curcumin loading into HKUST-1 at various mass ratios (1:1, 1:2, 1:3).
  • Characterization using FTIR, X-ray diffraction, TGA, and BET analysis.
  • Biological evaluation including antioxidant assays, MTT assays, and antibacterial tests.

Main Results:

  • Successful synthesis of curcumin-loaded HKUST-1, preserving its crystalline structure.
  • The 1:1 curcumin:HKUST-1 ratio exhibited the highest drug loading capacity and efficiency.
  • Curcumin-loaded HKUST-1 demonstrated concentration-dependent antioxidant activity (62.22% radical scavenging at 200 μg/mL).
  • Excellent antibacterial performance against E. coli and S. aureus (>99% inhibition).
  • Improved cell viability in human dermal fibroblasts compared to pristine HKUST-1.

Conclusions:

  • Curcumin-loaded HKUST-1 is a stable, biocompatible, and pH-responsive MOF system.
  • The 1:1 formulation shows significant promise for controlled drug delivery.
  • This system holds strong potential for antimicrobial applications and enhanced therapeutic outcomes.