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Portal Hypertension

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Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
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Related Experiment Video

Updated: May 2, 2026

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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Haemochromatosis - a modern clinician's guide.

James G Fiori1, John K Olynyk1,2

  • 1Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Perth, Western Australia, Australia.

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|April 30, 2026
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Haemochromatosis, an inherited iron overload disorder, affects 100,000 Australians. Early diagnosis and venesection treatment can prevent or reverse organ damage, improving patient outcomes.

Keywords:
HFE haemochromatosisiron overload

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Area of Science:

  • Medical Genetics
  • Gastroenterology
  • Endocrinology

Background:

  • Haemochromatosis is a common inherited iron metabolism disorder.
  • Iron overload can lead to significant end-organ damage, including liver disease, joint problems, and hormonal imbalances.
  • Recent advances include identifying HFE gene variants and understanding sex-specific differences.

Purpose of the Study:

  • To provide a clinical perspective on haemochromatosis.
  • To summarize current evidence on pathophysiology, clinical features, and treatment.
  • To highlight the importance of early diagnosis and management.

Main Methods:

  • Review of up-to-date evidence.
  • Clinical perspective article.
  • Summary of pathophysiology, epidemiology, and treatment.

Main Results:

  • Haemochromatosis affects approximately 100,000 Australians.
  • Common complications include chronic liver disease, arthropathy, and endocrinopathies.
  • Early diagnosis and venesection are key to preventing or reversing complications.

Conclusions:

  • Haemochromatosis management relies on early detection and venesection.
  • Understanding genetic and sex-specific factors improves care.
  • Timely intervention prevents severe end-organ dysfunction.