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Hospital Care for Pediatric Stroke in the United States: Resource Utilization, Charges, Comorbidities, Death, and

Muhammad S Ghauri1, Lisa Pabst2, Samuel A Tenhoeve3

  • 1Loma Linda University Medical Center, Loma Linda, California.

Pediatric Neurology
|April 30, 2026
PubMed

Insights

Pediatric ischemic stroke hospitalizations have doubled, carrying significant mortality and health loss, especially in young children. Thrombectomy may reduce mortality, while non-home discharge increases costs.

Area of Science:

  • Neurology
  • Pediatrics
  • Public Health

Background:

  • Pediatric ischemic stroke incidence and prevalence are rising.
  • Healthcare utilization and outcomes for pediatric stroke are evolving.

Purpose of the Study:

  • To examine healthcare utilization and outcomes in pediatric ischemic stroke admissions in the U.S. over two decades.

Main Methods:

  • Cross-sectional study using Kids' Inpatient Database from 2003-2022.
  • Primary outcome: in-hospital death. Secondary outcomes: length of stay, discharge disposition, charges, and disability-adjusted life years (DALYs).

Main Results:

  • Hospitalizations increased by 105%, with overall mortality at 11%, highest in infants.
  • Younger age, non-pediatric hospitals, and self-pay were linked to higher mortality; thrombectomy showed a protective effect.
  • Total DALYs more than doubled, with the highest burden in children aged 1-4 years.

Conclusions:

  • Pediatric ischemic stroke imposes substantial mortality, resource burden, and lifetime health loss, particularly on the youngest.
  • Younger age, non-pediatric care, and self-pay status predict increased mortality; thrombectomy appears beneficial.
  • Findings underscore the economic impact and need for coordinated discharge planning and rehabilitation access.
Abstract

Keywords:
Disability-adjusted life yearsIn-hospital mortalityIschemic strokeOutcomesPediatricThrombectomy

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