Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evolution of Gas Film and Corresponding Drag Reduction Performance in Microchannels with Multi-Configuration Wall Microstructures.

Materials (Basel, Switzerland)·2026

Same author

Wavelet spectral-aware Kolmogorov-Arnold Network for organ and tumor segmentation.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society·2026

Same author

Smartphone-Based Proactive Self-Screening for Ocular Surface Malignancies: A Nonrandomized Clinical Trial.

JAMA ophthalmology·2026

Same author

Machine Anomalous Sound Detection Method Based on Lightweight Temporal Pyramid and ECA-MobileFaceNet.

Sensors (Basel, Switzerland)·2026

Same author

Modular living assembly of bone organoids with in situ guided vascularization.

Bioactive materials·2026

Same author

Linking molecular architecture to antibacterial functions: a chemical biology view of cyclic depsipeptides.

Frontiers in chemistry·2026

Same journal

A flap mechanics testbed for skin reconstructive surgery: Evaluating the mechanical interaction between flap design and anisotropy.

Acta biomaterialia·2026

Same journal

Diabetes Alters Protein Corona to Reprogram Wear Particle-Cell Interaction.

Acta biomaterialia·2026

Same journal

Matrix mechanics couple contractility to metabolic adaptation in cancer cells.

Acta biomaterialia·2026

Same journal

Porous ZnO/Zn scaffolds fabricated using binder-jetting 3D printing promote bone regeneration: in vitro and in vivo evidence.

Acta biomaterialia·2026

Same journal

Potential-gradient reprogramming of zinc-based membranes for orthopedic applications.

Acta biomaterialia·2026

Same journal

Wavy Geometry Controls Nuclear Morphology, Migration, and YAP Signaling Independent of Myosin II Contractility.

Acta biomaterialia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Tendon-Bone junction organoids: Construction and application.

Ruiyang Li¹, Yuezhou Wu¹, Zhu'anzhen Zheng²

¹Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; MedEng-X Institutes, Shanghai University, Shanghai 200444, China; Trauma Orthopedics Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai 200444, China.

Acta Biomaterialia

|April 30, 2026

Summary

This summary is machine-generated.

Tendon-bone healing is complex, and current treatments are often unpredictable. Organoid technology offers a promising new way to model this healing process and test new therapies for better outcomes.

Keywords:

Biomaterials Gradient scaffolds Organoids Tendon-bone healing Tendon-bone junction

More Related Videos

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

Related Experiment Videos

Last Updated: May 2, 2026

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

Area of Science:

Regenerative Medicine
Biomaterials Science
Tissue Engineering

Background:

Tendon-bone healing is a complex biological process influenced by numerous factors, leading to suboptimal clinical outcomes.
Existing experimental models often fail to fully replicate the intricate nature of the tendon-bone junction, hindering therapeutic development.
There is a critical need for advanced platforms to accurately model tendon-bone healing and evaluate combination therapies.

Purpose of the Study:

To provide a comprehensive review of tendon-bone anatomy and healing mechanisms.
To highlight the latest therapeutic strategies for promoting tendon-bone healing, including cell-based therapies, biomimetic scaffolds, and external stimulations.
To discuss the potential applications and challenges of biomaterials in developing tendon-bone junction organoids.

Main Methods:

Review of existing literature on tendon-bone healing mechanisms and therapeutic strategies.
Exploration of organoid culture technology as a novel research tool for simulating biological structures.
Integration of therapeutic approaches with tendon-bone junction organoid development for enhanced modeling.

Main Results:

Organoid culture technology offers a promising approach to create three-dimensional tissues that mimic natural biological structures.
Integrating therapeutic strategies into tendon-bone junction organoids can accurately simulate the native healing environment.
Biomaterial-enhanced organoids are expected to accelerate the development of effective tendon-bone repair strategies.

Conclusions:

Tendon-bone junction organoids represent a significant advancement for modeling complex healing processes.
This innovative approach holds the potential to improve the efficacy and predictability of tendon-bone healing therapies.
Continued advancements in organoid technology are crucial for developing personalized strategies to enhance tendon-bone repair.