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Updated: May 2, 2026

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Tendon-Bone junction organoids: Construction and application.

Ruiyang Li¹, Yuezhou Wu¹, Zhu'anzhen Zheng²

¹Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; MedEng-X Institutes, Shanghai University, Shanghai 200444, China; Trauma Orthopedics Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai 200444, China.

Acta Biomaterialia

|April 30, 2026

Summary

This summary is machine-generated.

Tendon-bone healing is complex, and current treatments are often unpredictable. Organoid technology offers a promising new way to model this healing process and test new therapies for better outcomes.

Keywords:

Biomaterials Gradient scaffolds Organoids Tendon-bone healing Tendon-bone junction

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Area of Science:

Regenerative Medicine
Biomaterials Science
Tissue Engineering

Background:

Tendon-bone healing is a complex biological process influenced by numerous factors, leading to suboptimal clinical outcomes.
Existing experimental models often fail to fully replicate the intricate nature of the tendon-bone junction, hindering therapeutic development.
There is a critical need for advanced platforms to accurately model tendon-bone healing and evaluate combination therapies.

Purpose of the Study:

To provide a comprehensive review of tendon-bone anatomy and healing mechanisms.
To highlight the latest therapeutic strategies for promoting tendon-bone healing, including cell-based therapies, biomimetic scaffolds, and external stimulations.
To discuss the potential applications and challenges of biomaterials in developing tendon-bone junction organoids.

Main Methods:

Review of existing literature on tendon-bone healing mechanisms and therapeutic strategies.
Exploration of organoid culture technology as a novel research tool for simulating biological structures.
Integration of therapeutic approaches with tendon-bone junction organoid development for enhanced modeling.

Main Results:

Organoid culture technology offers a promising approach to create three-dimensional tissues that mimic natural biological structures.
Integrating therapeutic strategies into tendon-bone junction organoids can accurately simulate the native healing environment.
Biomaterial-enhanced organoids are expected to accelerate the development of effective tendon-bone repair strategies.

Conclusions:

Tendon-bone junction organoids represent a significant advancement for modeling complex healing processes.
This innovative approach holds the potential to improve the efficacy and predictability of tendon-bone healing therapies.
Continued advancements in organoid technology are crucial for developing personalized strategies to enhance tendon-bone repair.