Cross-linked actin networks (CLANs) and their role in the trabecular meshwork
Aileen Huang1, Joseph M Dalloul1, Chenna Kesavulu Sugali1
1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States.
None:
Glaucoma is a leading cause of irreversible blindness worldwide, characterized by progressive optic neuropathy commonly associated with elevated intraocular pressure (IOP). The trabecular meshwork (TM) is a critical regulator of aqueous humor outflow, and its biological and biomechanical properties directly influence IOP homeostasis. In glaucomatous eyes and in response to various glaucomatous stimuli, TM cells form cross-linked actin networks (CLANs), a special geodesic actin structure. CLANs alter cytoskeletal dynamics, increase cell stiffness, and impair TM function. This review summarizes past and recent research of CLANs, including their inducers, effects on the TM, and role in glaucoma pathogenesis, as well as suggests some future research directions.
Related Concept Videos
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Tension Response at Adherens Junctions
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
Tight Junctions
Formation of Higher-order Actin Filaments
The high-order actin...
Intracellular Signaling Affects Focal Adhesions
Some...
Anchoring Junctions


