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Home
Mid-range Arc Therapy For Efficient And Rbe-robust Proton Treatment.

Home
Mid-range Arc Therapy For Efficient And Rbe-robust Proton Treatment.

Related Experiment Video

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Mid-range arc therapy for efficient and RBE-robust proton treatment.

Qingying Wang¹, Mingli Chen¹, Yinheng Zhu¹

¹Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, United States of America.

Physics in Medicine and Biology

|April 30, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Mid-Range Proton Arc Therapy (MRPAT) offers an efficient solution for proton arc therapy, improving delivery speed and containing biological uncertainties within the target. This novel approach enhances normal tissue sparing and is practical for clinical implementation.

Keywords:

LETd RBE-robust delivery efficiency energy layer selection proton arc therapy

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Area of Science:

Medical Physics
Radiation Oncology
Radiotherapy Planning

Background:

Proton arc therapy (PAT) presents challenges in clinical translation due to radiobiological uncertainties and delivery inefficiencies.
Existing methods require optimization for improved plan conformity and normal tissue sparing.

Purpose of the Study:

Introduce Mid-Range Proton Arc Therapy (MRPAT), a novel planning approach for PAT.
Enhance delivery efficiency and mitigate range-related uncertainties in proton therapy.

Main Methods:

MRPAT utilizes a single mid-range energy layer (MREL) per beam direction, placing the Bragg peak centrally within the target.
Investigated feasibility using an ellipse phantom and clinical cases (prostate, spine, head and neck).
Compared physical dose, LETd, RBE-weighted dose, and delivery efficiency against Full-Arc and intensity-modulated proton therapy (IMPT).

Main Results:

MRPAT achieved comparable target coverage and OAR sparing to Full-Arc plans, indicating energy layer redundancy.
Effectively confined high LETd and RBE hotspots to the target center, reducing spillage.
MRPAT significantly improved delivery efficiency, reducing beam delivery time by approximately 80% compared to Full-Arc.

Conclusions:

MRPAT is a simple, efficient planning concept for PAT.
Demonstrates practical clinical utility and adaptability for future adaptive radiotherapy workflows.
Effectively contains high dose-gradient regions, improving safety and efficacy.