Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

558
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
558
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

2.0K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
2.0K
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

541
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
541
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in Acute Ischemic Stroke 2025: Medical Treatments.

Stroke·2026
Same author

Editorial for "Infant Brain Age Estimation With T1w/T2w Ratio MRI: A Myelination-Aware Deep Learning Approach".

Journal of magnetic resonance imaging : JMRI·2026
Same author

Stroke Severity and Functional Benefit of Thrombectomy in Acute M2 Middle Cerebral Artery Occlusion: A Multicenter Cohort Study.

Neurology·2026
Same author

Ischemic Lesion Net Water Uptake Outperforms ASPECTS and CBF Less Than 30% in Predicting Futile Recanalization after Mechanical Thrombectomy.

Radiology·2026
Same author

Revisiting Revascularization Timing in Acute Stroke Due to Intracranial Atherosclerotic Stenosis: Is It Time to Act Earlier?

Neurology·2026
Same author

Chinese stroke association guidelines on construction of direct transfer to angiography suite.

Stroke and vascular neurology·2026
Same journal

CT-Guided Epidural Blood Patch for Postoperative Lumbar Cerebrospinal Fluid Leak: A Case Series and Clinical Outcomes.

AJNR. American journal of neuroradiology·2026
Same journal

Clinical Outcomes of Isolated Subarachnoid Hemorrhage after Mechanical Thrombectomy.

AJNR. American journal of neuroradiology·2026
Same journal

Validation of an Automated ASPECTS Software via a Multi-Reader Multi-Case Clinical Reader Study.

AJNR. American journal of neuroradiology·2026
Same journal

Gender Trends in Authorship Across Neuroradiology Journals (2016-2025).

AJNR. American journal of neuroradiology·2026
Same journal

Outcomes of Endovascular Treatment in Large Vessel Occlusions Due to Intracranial Atherosclerotic Disease: A Systematic Review and Updated Meta-Analysis of 11,326 Patients.

AJNR. American journal of neuroradiology·2026
Same journal

Quantitative Impact of T1 Subtraction Maps on Enhancing Component Delineation and Measured Volumes in Minimally Enhancing Pediatric Brain Tumors.

AJNR. American journal of neuroradiology·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

3.2K

Microcirculatory Collaterals Modulate Ischemic Core Heterogeneity on Diffusion-Weighted Imaging.

Aroosa Zamarud1, Michael Mlynash2, Nicole Yuen2

  • 1From the Department of Radiology (A.Z., H.v.V., M.S., S.D., J.J.H.), Stanford University School of Medicine, Stanford, California.

AJNR. American Journal of Neuroradiology
|April 30, 2026
PubMed
Summary
This summary is machine-generated.

Good collateral blood flow, indicated by a low hypoperfusion intensity ratio (HIR), is linked to less variability in the ischemic core on diffusion-weighted imaging (DWI) in acute ischemic stroke patients. This finding helps refine stroke assessment and treatment strategies.

More Related Videos

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling
16:43

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

12.1K
Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels
13:16

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels

Published on: January 4, 2013

15.0K

Related Experiment Videos

Last Updated: May 2, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

3.2K
Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling
16:43

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

12.1K
Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels
13:16

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels

Published on: January 4, 2013

15.0K

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Endovascular thrombectomy (EVT) is a key treatment for acute ischemic stroke due to large vessel occlusion (AIS-LVO).
  • Diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) maps is standard for defining the ischemic core, but ADC values can be heterogeneous.
  • Tissue-level collateral status, assessed by hypoperfusion intensity ratio (HIR) from perfusion imaging, may influence this heterogeneity.

Purpose of the Study:

  • To investigate how tissue-level collaterals, measured by HIR, affect the heterogeneity of the ischemic core in patients with AIS-LVO.
  • To analyze the relationship between HIR and ADC variability within the ischemic core.

Main Methods:

  • Post hoc analysis of the CRISP 2 study involving patients with AIS-LVO.
  • Patients underwent baseline CT perfusion and follow-up MRI perfusion before EVT.
  • Patients were stratified by HIR (favorable ≤0.5 vs. unfavorable >0.5) to assess ADC variability within the ischemic core (ADC ≤620 × 10-6 mm²/s).

Main Results:

  • Favorable HIR was associated with lower NIHSS scores, smaller hypoperfusion and ischemic core volumes, and less frequent IV thrombolysis use.
  • ADC heterogeneity (standard deviation) was significantly lower in patients with favorable HIR (167.2 vs. 193.5, P=.01).
  • HIR was independently associated with ADC standard deviation and coefficient of variation.

Conclusions:

  • Favorable tissue-level collaterals, indicated by a low HIR, are associated with reduced ischemic core ADC heterogeneity.
  • This suggests collateral status is an important factor in characterizing the ischemic core in AIS-LVO.